Netrin-activated signaling pathway

Across TCGA cell cohorts, RNA activity of the Netrin-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB561D1, ERC1, and MTA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB561D1 grouped by Netrin-activated signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CYB561D1 →	-0.667	-1.357	.008	<.001	3	6
PANCREAS	ERC1 →	-1.250	-1.047	.008	.005	3	5
LARGE_INTESTINE	MTA1 →	-0.593	-0.653	.004	.007	3	4
CNS	SNRNP35 →	-0.476	-1.149	.002	<.001	3	4
LIVER	HLCS →	-0.958	-1.577	.002	<.001	3	4
OESOPHAGUS	KLC1 →	-0.862	-1.306	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB561D1 by Netrin-activated signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →