G protein-coupled opioid receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled opioid receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, OSBPL3, and ID4_S5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled opioid receptor signaling pathway activity versus UPP1 in HNSC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UPP1 →	+0.759	+0.108	<.001	.001	3	6
LUAD	OSBPL3 →	+0.378	+0.123	<.001	.002	3	6
BRCA	ID4_S5 →	-1.110	-0.103	<.001	<.001	3	5
HNSC	TRIM21_S266 →	+0.532	+0.110	<.001	<.001	3	5
OV	AFAP1L2_T541 →	+0.724	+0.093	.003	.002	3	5
HNSC	KAT7 →	-0.241	-0.098	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038003 vs UPP1 — HNSC

Explore this scatter interactively →