Paracrine signaling

Across TCGA patient cohorts, RNA activity of the Paracrine signaling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, TGFBI_S649, and POP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Paracrine signaling activity versus RPL12_S38 in LSCC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPL12_S38 →	-0.706	-0.045	<.001	.001	3	6
LSCC	TGFBI_S649 →	+1.104	+0.052	<.001	.002	3	6
LSCC	POP1 →	-0.160	-0.039	<.001	.006	3	6
PDAC	SERPINA5 →	+0.455	+0.053	.002	.006	2	6
LSCC	CHERP →	-0.205	-0.050	<.001	<.001	3	5
GBM	DPP4 →	+1.334	+0.113	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038001 vs RPL12_S38 — LSCC

Explore this scatter interactively →