Paracrine signaling

Across TCGA patient cohorts, RNA activity of the Paracrine signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGR, SCUBE1, and KCNK6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Paracrine signaling activity versus PGR in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PGR →	+2.405	+0.827	<.001	<.001	3	4
BRCA	SCUBE1 →	+0.657	+0.629	<.001	<.001	3	4
BRCA	KCNK6 →	+0.921	+0.623	<.001	<.001	3	4
BRCA	ADGRG6 →	-1.154	-0.500	<.001	<.001	3	3
UCEC	ANO1 →	+1.399	+0.260	<.001	<.001	3	3
UCEC	SP6 →	-0.791	-0.192	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038001 vs PGR — BRCA

Explore this scatter interactively →