ATF6-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the ATF6-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF15, RFC3, and KIF20A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ATF6-mediated unfolded protein response activity versus KIF15 in LUAD (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF15 →	-0.578	-0.293	.004	.001	3	5
HNSC	RFC3 →	-0.729	-0.509	<.001	.003	3	4
LUAD	KIF20A →	-0.638	-0.266	<.001	<.001	3	4
LUAD	LMNB1 →	-0.465	-0.274	.006	.003	3	4
HNSC	FANCD2 →	-0.444	-0.727	.008	<.001	2	5
HNSC	ESCO2 →	-0.531	-0.485	<.001	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036500 vs KIF15 — LUAD

Explore this scatter interactively →