PERK-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the PERK-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RARB, TPM1, and SLC2A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RARB grouped by PERK-mediated unfolded protein response-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RARB →	+1.954	+0.405	<.001	<.001	3	4
LUNG_NSCLC_LUSC	TPM1 →	-2.868	-0.298	.006	.008	3	4
BLOOD_Lymphoma	SLC2A1 →	+0.944	+0.589	.004	<.001	3	3
BLOOD_Lymphoma	SIK1B →	+1.710	+0.572	.001	.009	3	3
SKIN	FAM50A →	-0.621	-0.584	<.001	.005	3	3
OVARY	MECR →	-0.457	-0.613	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RARB by PERK-mediated unfolded protein response activity — LIVER

Explore this box plot interactively →