Synaptic vesicle recycling via endosome

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle recycling via endosome pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COASY, GAS2, and CCDC137, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle recycling via endosome activity versus COASY in LSCC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COASY →	-0.333	-0.103	.007	.008	3	5
CCRCC	GAS2 →	-0.525	-0.177	.005	.004	3	4
LSCC	CCDC137 →	-0.376	-0.120	.002	.004	3	4
OV	LRRC37A3 →	-0.801	-0.474	<.001	.006	3	3
UCEC	MIR29B2CHG →	+0.545	+0.146	.004	.009	3	3
UCEC	LINC00921 →	+0.412	+0.125	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036466 vs COASY — LSCC

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