Myofibroblast differentiation

Across TCGA patient cohorts, RNA activity of the Myofibroblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, COLEC12, and DCN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myofibroblast differentiation activity versus BGN in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BGN →	+0.695	+0.105	<.001	.004	3	9
OV	COLEC12 →	+0.748	+0.089	.001	.003	3	9
BRCA	DCN →	+0.934	+0.093	<.001	<.001	3	9
GBM	HSPG2 →	+0.513	+0.073	<.001	<.001	3	9
BRCA	LRP1 →	+0.604	+0.112	<.001	<.001	3	9
BRCA	PCOLCE →	+0.727	+0.095	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036446 vs BGN — UCEC

Explore this scatter interactively →