Myofibroblast differentiation

Across TCGA cell cohorts, RNA activity of the Myofibroblast differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND5A, GHR, and FUT8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENND5A grouped by Myofibroblast differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DENND5A →	-0.228	-0.243	<.001	.004	3	4
BREAST	GHR →	-0.130	-0.452	<.001	.005	3	4
KIDNEY	FUT8 →	-0.252	-0.182	.003	.003	3	3
BLOOD_Leukemia	CHRM3 →	+0.225	+0.155	.009	.004	3	3
BLOOD_Leukemia	CXCL9 →	-0.161	-0.136	.009	.006	3	3
BLOOD_Leukemia	CES1P2 →	+0.290	+0.212	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENND5A by Myofibroblast differentiation activity — SOFT_TISSUE

Explore this box plot interactively →