Calcium import into the mitochondrion

Across TCGA patient cohorts, RNA activity of the Calcium import into the mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GOLIM4_S364, QSOX1, and TLN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium import into the mitochondrion activity versus GOLIM4_S364 in OV (Pearson r = -0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GOLIM4_S364 →	-1.304	-0.130	<.001	<.001	3	5
UCEC	QSOX1 →	-0.573	-0.079	.004	.003	3	5
OV	TLN1 →	+0.216	+0.049	<.001	<.001	3	4
OV	COPZ2 →	+0.697	+0.059	.002	<.001	3	4
OV	IFIT1 →	+0.699	+0.057	<.001	<.001	3	4
PDAC	EPB41L1_S578 →	+0.974	+0.055	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036444 vs GOLIM4_S364 — OV

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