Calcium import into the mitochondrion

Across TCGA cell cohorts, RNA activity of the Calcium import into the mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A23, MCU, and PCBD1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium import into the mitochondrion activity versus SLC25A23 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SLC25A23 →	+1.203	+0.100	<.001	<.001	3	12
STOMACH	MCU →	+1.127	+0.120	<.001	<.001	3	12
OESOPHAGUS	PCBD1 →	+1.312	+0.085	<.001	<.001	3	9
STOMACH	ANXA11 →	+1.271	+0.118	.003	<.001	3	9
CNS	MICU3 →	-0.642	-0.079	.001	.001	3	9
OESOPHAGUS	ANAPC16 →	+0.914	+0.104	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036444 vs SLC25A23 — UPPER_AERODIGESTIVE_TRACT

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