Calcium import into the mitochondrion

Across TCGA cell cohorts, RNA activity of the Calcium import into the mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFG3L2, SEH1L, and ELL2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium import into the mitochondrion activity versus AFG3L2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	AFG3L2 →	+0.964	+0.151	.001	.001	2	14
OESOPHAGUS	SEH1L →	+0.954	+0.186	<.001	.004	3	7
SKIN	ELL2 →	-1.144	-0.101	<.001	.003	3	7
PANCREAS	CEP192 →	+0.765	+0.132	<.001	.006	3	6
LUNG_SCLC	NAPG →	+0.910	+0.137	.007	.001	3	5
LUNG_SCLC	PSMG2 →	+0.931	+0.117	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036444 vs AFG3L2 — UPPER_AERODIGESTIVE_TRACT

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