Maintenance of lens transparency

Across TCGA patient cohorts, RNA activity of the Maintenance of lens transparency pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, PIK3C2A, and SOS1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of lens transparency activity versus PPP1R12A in UVM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	PPP1R12A →	+1.281	+0.056	<.001	<.001	3	32
UVM	PIK3C2A →	+1.477	+0.038	<.001	<.001	3	31
UVM	SOS1 →	+1.158	+0.049	.001	<.001	3	31
UVM	CREB1 →	+0.911	+0.039	<.001	<.001	3	31
UCS	ATAD2B →	+0.883	+0.077	<.001	<.001	3	31
CHOL	VPS13B →	+1.310	+0.066	<.001	<.001	2	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036438 vs PPP1R12A — UVM

Explore this scatter interactively →