Sodium ion export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Sodium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A4, LDHAL6EP, and COLCA1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion export across plasma membrane activity versus SLC4A4 in PDAC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A4 →	+1.602	+0.751	<.001	<.001	3	8
GBM	LDHAL6EP →	+1.320	+0.479	<.001	<.001	3	6
LUAD	COLCA1 →	+0.916	+0.673	.001	.002	3	6
BRCA	HROB →	-0.423	-1.026	.006	<.001	3	5
PDAC	HPN →	+1.603	+0.934	<.001	<.001	3	5
PDAC	RGN →	+0.763	+0.734	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036376 vs SLC4A4 — PDAC

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