Platelet morphogenesis

Across TCGA patient cohorts, RNA activity of the Platelet morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSP1_S252, INPP5D_S243, and CLIC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet morphogenesis activity versus LSP1_S252 in GBM (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LSP1_S252 →	+0.546	+0.045	<.001	<.001	3	6
GBM	INPP5D_S243 →	+0.551	+0.046	<.001	<.001	3	6
GBM	CLIC2 →	+0.537	+0.053	<.001	<.001	3	6
GBM	ARHGAP30 →	+0.619	+0.053	<.001	<.001	3	6
GBM	SNTB2_S222 →	+0.797	+0.050	<.001	.004	3	5
GBM	FERMT3 →	+0.658	+0.069	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036344 vs LSP1_S252 — GBM

Explore this scatter interactively →