Platelet morphogenesis

Across TCGA patient cohorts, RNA activity of the Platelet morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS25, PSMC3, and FNDC9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet morphogenesis activity versus VPS25 in HNSC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VPS25 →	-0.534	-0.495	.007	.003	3	4
HNSC	PSMC3 →	-0.904	-0.710	.002	.002	3	4
COAD	FNDC9 →	+0.015	+0.697	.009	.009	3	4
CCRCC	ADAMTSL2 →	+0.651	+0.442	.007	.004	3	4
OV	ZNF503 →	+0.705	+0.625	.007	.008	3	4
UCEC	PSMC4 →	-0.712	-0.524	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036344 vs VPS25 — HNSC

Explore this scatter interactively →