Fas signaling pathway

Across TCGA patient cohorts, RNA activity of the Fas signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZCCHC24, STK10, and DPYD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fas signaling pathway activity versus ZCCHC24 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZCCHC24 →	+0.436	+0.133	<.001	<.001	3	9
GBM	STK10 →	+0.443	+0.128	<.001	<.001	3	9
GBM	DPYD →	+0.573	+0.097	<.001	<.001	3	9
LSCC	LRPPRC →	-0.547	-0.095	<.001	<.001	3	9
BRCA	PTCD3 →	-0.319	-0.098	<.001	<.001	3	9
LSCC	WIPF1 →	+0.382	+0.116	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036337 vs ZCCHC24 — LSCC

Explore this scatter interactively →