Fas signaling pathway

Across TCGA patient cohorts, RNA activity of the Fas signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SP100, SP100_S394, and SP100_S362, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fas signaling pathway activity versus SP100 in GBM (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SP100 →	+0.612	+0.686	<.001	<.001	3	6
CCRCC	SP100_S394 →	+0.870	+0.494	<.001	<.001	3	5
GBM	SP100_S362 →	+0.606	+0.501	<.001	<.001	3	5
GBM	STAT2 →	+0.681	+0.811	<.001	<.001	3	4
GBM	RNF213 →	+0.364	+0.612	<.001	<.001	3	4
GBM	TRIM21 →	+0.440	+0.592	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036337 vs SP100 — GBM

Explore this scatter interactively →