Fas signaling pathway

Across TCGA cell cohorts, RNA activity of the Fas signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM23, BCAS4, and GPR55, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fas signaling pathway activity versus ADAM23 in BLOOD_Lymphoma (Pearson r = 0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ADAM23 →	+4.834	+1.575	.004	.001	1	2
BLOOD_Lymphoma	BCAS4 →	-3.380	-1.575	.001	.001	1	2
BLOOD_Lymphoma	GPR55 →	+3.520	+1.575	.003	.001	1	2
BLOOD_Lymphoma	RNF157 →	+4.350	+1.575	.008	.001	1	2
BLOOD_Lymphoma	TSPAN7 →	+3.239	+1.575	.002	.001	1	2
BLOOD_Lymphoma	SNX22 →	-4.340	-1.575	.003	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036337 vs ADAM23 — BLOOD_Lymphoma

Explore this scatter interactively →