Fas signaling pathway

Across TCGA cell cohorts, RNA activity of the Fas signaling pathway pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Thapsigargin, BDOCA000347a, and GNE-317, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Thapsigargin grouped by Fas signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Thapsigargin →	-1.403	-1.766	.003	.004	3	3
BLOOD_Lymphoma	BDOCA000347a →	+0.417	+1.657	.016	<.001	3	3
BLOOD_Lymphoma	GNE-317 →	-0.521	-0.971	.032	.042	3	2
BLOOD_Lymphoma	Phenformin →	-1.700	-1.526	<.001	<.001	3	2
BLOOD_Lymphoma	CX-5461 →	-1.804	-1.721	.010	<.001	3	2
BLOOD_Leukemia	Topotecan →	-0.843	-1.858	.037	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Thapsigargin by Fas signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →