Dendritic cell migration

Across TCGA cell cohorts, RNA activity of the Dendritic cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42, GPR183, and OTX2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC42 grouped by Dendritic cell migration-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CDC42 →	-0.347	-1.128	.001	<.001	3	7
PANCREAS	GPR183 →	-0.261	-1.118	.004	.003	3	5
BLOOD_Myeloma	OTX2 →	-0.366	-1.668	.008	.001	3	5
LUNG_SCLC	FOXE1 →	-0.379	-1.552	<.001	<.001	3	5
LUNG_SCLC	EYA2 →	-0.242	-1.179	<.001	<.001	3	5
BREAST	CCL5 →	-0.228	-0.796	.007	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC42 by Dendritic cell migration activity — LUNG_SCLC

Explore this box plot interactively →