Vascular endothelial growth factor receptor-2 signaling pathway

Across TCGA patient cohorts, RNA activity of the Vascular endothelial growth factor receptor-2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2IP, EDN1, and SNW1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular endothelial growth factor receptor-2 signaling pathway activity versus DAB2IP in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DAB2IP →	+0.602	+0.700	<.001	<.001	3	4
CCRCC	EDN1 →	+1.560	+0.630	<.001	.001	3	4
COAD	SNW1 →	+0.339	+0.121	.004	<.001	3	3
PDAC	PRPF40B →	-0.291	-0.527	<.001	<.001	3	3
PDAC	IQSEC1 →	-0.404	-0.391	.001	.003	3	3
LUAD	MIR148A →	-0.655	-0.450	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036324 vs DAB2IP — LSCC

Explore this scatter interactively →