Ameloblast differentiation

Across TCGA patient cohorts, RNA activity of the Ameloblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FSCN1_S39, COL12A1, and FST, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ameloblast differentiation activity versus FSCN1_S39 in LSCC (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FSCN1_S39 →	+0.713	+0.144	<.001	<.001	3	7
PDAC	COL12A1 →	+0.868	+0.130	<.001	<.001	3	6
OV	FST →	+1.235	+0.223	.001	<.001	3	6
LUAD	THBS1 →	+0.618	+0.069	.006	.004	3	6
LUAD	PPFIBP1 →	+0.221	+0.104	<.001	.004	3	6
OV	THBS3 →	+0.455	+0.124	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036305 vs FSCN1_S39 — LSCC

Explore this scatter interactively →