Atrioventricular canal development

Across TCGA patient cohorts, RNA activity of the Atrioventricular canal development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB1, SEPTIN11, and LAMC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular canal development activity versus LAMB1 in LUAD (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LAMB1 →	+0.418	+0.118	<.001	<.001	3	8
OV	SEPTIN11 →	+0.396	+0.070	<.001	.001	3	8
LUAD	LAMC1 →	+0.412	+0.104	<.001	<.001	3	7
UCEC	NID1 →	+0.454	+0.093	.002	.001	3	7
LUAD	HAAO →	+0.257	+0.072	<.001	<.001	3	7
LSCC	NES_S768 →	+0.735	+0.121	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036302 vs LAMB1 — LUAD

Explore this scatter interactively →