Interstrand cross-link repair

Across TCGA patient cohorts, RNA activity of the Interstrand cross-link repair pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP128, PPP4R3A, and ADNP, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interstrand cross-link repair activity versus CEP128 in THYM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	CEP128 →	+1.622	+0.057	<.001	<.001	3	34
UVM	PPP4R3A →	+1.452	+0.053	<.001	<.001	3	34
DLBC	ADNP →	+1.403	+0.075	<.001	<.001	3	34
DLBC	TTI1 →	+1.168	+0.074	<.001	<.001	3	34
KICH	RPRD1B →	+1.220	+0.051	<.001	<.001	3	34
DLBC	CEP76 →	+0.913	+0.058	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036297 vs CEP128 — THYM

Explore this scatter interactively →