Interstrand cross-link repair

Across TCGA pan-cancer cohorts, RNA activity of the Interstrand cross-link repair pathway is associated with patient survival in 30 of 34 cancer lineages. Pathway activity is summarized from the expression of its 40 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Interstrand cross-link repair pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and HNSC, show the opposite pattern, with higher activity associated with better survival.

ACC, MESO, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.367	0.765	<.001	152	view →
MESO	OS	Tertile	All	0.395	0.668	<.001	123	view →
KIRC	DFS	Tertile	All	0.467	0.693	<.001	106	view →
KICH	DFS	Median	All	0.588	0.957	<.001	102	view →
LIHC	OS	Median	All	0.593	0.761	<.001	76	view →
READ	OS	Median	II,III,IV	0.876	0.458	.001	74	view →
HNSC	OS	Median	All	0.477	0.336	.002	63	view →
LGG	DFS	Median	All	0.643	0.808	<.001	54	view →
KIRP	OS	Tertile	All	0.591	0.801	<.001	52	view →
UCS	OS	Median	IV	0.844	0.234	.005	48	view →
SCLC	DFS	Tertile	II,III,IV	0.605	0.212	.004	34	view →
LUAD	OS	Median	All	0.754	0.847	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

GO:0036297–ACC (DFS)

Open the ACC breakdown →