Interstrand cross-link repair

Across TCGA patient cohorts, RNA activity of the Interstrand cross-link repair pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOMO2, ANKRD65, and IGF2BP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interstrand cross-link repair activity versus NOMO2 in CCRCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NOMO2 →	-0.501	-0.634	<.001	.002	3	3
CCRCC	ANKRD65 →	+0.407	+0.625	.002	<.001	3	3
LUAD	IGF2BP3 →	-0.948	-0.060	<.001	.005	3	3
LUAD	RNA5SP466 →	-0.550	-0.080	.003	.007	3	3
BRCA	BLM →	+0.690	+1.083	<.001	<.001	3	3
LSCC	ATP13A4-AS1 →	-1.067	-0.999	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036297 vs NOMO2 — CCRCC

Explore this scatter interactively →