Interstrand cross-link repair

Across TCGA cell cohorts, RNA activity of the Interstrand cross-link repair pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2D, TONSL, and TFRC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMK2D grouped by Interstrand cross-link repair-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CAMK2D →	+2.066	+0.223	.001	.002	3	5
BONE	TONSL →	+2.064	+0.292	.003	.003	3	5
KIDNEY	TFRC →	-1.392	-0.298	.002	<.001	3	5
OESOPHAGUS	PAQR7 →	+1.741	+0.190	.002	<.001	3	4
BONE	ZC3H3 →	+1.009	+0.314	.001	.001	3	4
BONE	ZMYM3 →	+1.372	+0.309	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMK2D by Interstrand cross-link repair activity — BLOOD_Leukemia

Explore this box plot interactively →