Interstrand cross-link repair

Across TCGA cell cohorts, RNA activity of the Interstrand cross-link repair pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIPA1L2, C1orf43, and SELENBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interstrand cross-link repair activity versus SIPA1L2 in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SIPA1L2 →	+2.926	+0.236	<.001	.001	3	6
BLOOD_Myeloma	C1orf43 →	+0.922	+0.214	.005	.002	3	6
LUNG_NSCLC_LUSC	SELENBP1 →	+2.838	+0.286	.002	.008	3	5
BLOOD_Lymphoma	RAPGEF2 →	+1.384	+0.165	.003	.001	3	5
BLOOD_Lymphoma	DUSP16 →	+2.008	+0.202	<.001	.004	3	5
BLOOD_Lymphoma	SDE2 →	+0.725	+0.236	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036297 vs SIPA1L2 — BLOOD_Lymphoma

Explore this scatter interactively →