Cellular response to increased oxygen levels

Across TCGA patient cohorts, RNA activity of the Cellular response to increased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRRS1, RALGPS1, and ZNF713, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to increased oxygen levels activity versus FRRS1 in COAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FRRS1 →	+0.451	+0.123	.005	.001	3	3
GBM	RALGPS1 →	-0.629	-0.113	<.001	.008	3	3
GBM	ZNF713 →	-0.732	-0.104	<.001	.002	3	3
BRCA	KCNMB1 →	+0.453	+0.118	<.001	<.001	3	3
BRCA	DOK3 →	+0.363	+0.090	.002	.008	3	3
BRCA	TOPBP1 →	-0.413	-0.164	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036295 vs FRRS1 — COAD

Explore this scatter interactively →