Cellular response to decreased oxygen levels

Across TCGA patient cohorts, RNA activity of the Cellular response to decreased oxygen levels pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANGPTL2, HTRA1, and FN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to decreased oxygen levels activity versus ANGPTL2 in BRCA (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANGPTL2 →	+0.603	+0.021	<.001	<.001	3	8
BRCA	HTRA1 →	+0.777	+0.023	.001	.001	3	8
COAD	FN1 →	+0.822	+0.022	<.001	.002	3	8
GBM	COL1A2 →	+0.793	+0.032	.001	.002	3	7
GBM	GTF2F1 →	-0.393	-0.041	<.001	<.001	3	7
BRCA	ITIH1 →	+0.681	+0.025	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036294 vs ANGPTL2 — BRCA

Explore this scatter interactively →