Cellular response to decreased oxygen levels

Across TCGA patient cohorts, RNA activity of the Cellular response to decreased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMD2, HMGB1P21, and POU6F2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to decreased oxygen levels activity versus LIMD2 in OV (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LIMD2 →	-0.830	-0.181	<.001	.004	3	3
LUAD	HMGB1P21 →	+1.378	+0.284	<.001	<.001	2	4
HNSC	POU6F2 →	-1.128	-0.165	.002	.003	3	3
HNSC	MELTF →	-0.983	-0.170	<.001	.002	3	3
LUAD	ETV4 →	-1.315	-0.225	.004	.003	3	3
COAD	LINC01142 →	+0.053	+0.117	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036294 vs LIMD2 — OV

Explore this scatter interactively →