Cellular response to decreased oxygen levels

Across TCGA cell cohorts, RNA activity of the Cellular response to decreased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT17, ADAM9, and TJP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYT17 grouped by Cellular response to decreased oxygen levels-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SYT17 →	-1.649	-0.236	.004	.007	3	5
CNS	ADAM9 →	+0.806	+0.132	.005	.002	3	5
STOMACH	TJP1 →	+1.227	+0.217	.005	.004	3	4
CNS	ATP6V1FNB →	+0.299	+0.131	.008	.003	3	4
BLOOD_Leukemia	MRPL3 →	-0.741	-0.184	.001	.008	3	3
SKIN	EEF1E1 →	-0.500	-0.191	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYT17 by Cellular response to decreased oxygen levels activity — SOFT_TISSUE

Explore this box plot interactively →