Cellular response to decreased oxygen levels

Across TCGA cell cohorts, RNA activity of the Cellular response to decreased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL10A, DDX21, and NOLC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to decreased oxygen levels activity versus RPL10A in PANCREAS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RPL10A →	-0.758	-0.374	<.001	.001	3	7
PANCREAS	DDX21 →	-1.052	-0.376	<.001	<.001	3	6
PANCREAS	NOLC1 →	-1.154	-0.341	<.001	<.001	3	6
SOFT_TISSUE	MAK16 →	-1.079	-0.229	.004	.007	3	6
BLOOD_Lymphoma	MRPL16 →	-0.687	-0.157	<.001	.001	3	6
PANCREAS	RPS9 →	-0.825	-0.323	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036294 vs RPL10A — PANCREAS

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