Peptidyl-serine autophosphorylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-serine autophosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPATCH4, NIFK_T223, and COIL_T303, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-serine autophosphorylation activity versus GPATCH4 in GBM (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GPATCH4 →	-0.526	-0.052	<.001	<.001	3	7
BRCA	NIFK_T223 →	-0.785	-0.046	.001	<.001	3	7
BRCA	COIL_T303 →	-1.001	-0.039	<.001	<.001	3	7
UCEC	NCAPH →	-0.662	-0.051	<.001	.009	3	7
BRCA	TRMT1L →	-0.313	-0.050	<.001	<.001	3	7
BRCA	UBE2T →	-0.838	-0.043	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036289 vs GPATCH4 — GBM

Explore this scatter interactively →