RNA (guanine-N7)-methylation

Across TCGA cell cohorts, RNA activity of the RNA (guanine-N7)-methylation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BUD23, IDH3B, and RNMT, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BUD23 grouped by RNA (guanine-N7)-methylation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BUD23 →	-0.348	-0.832	<.001	.001	3	9
OVARY	IDH3B →	-0.161	-1.123	.005	.008	3	4
LUNG_NSCLC_LUAD	RNMT →	-0.132	-0.551	<.001	<.001	3	4
BLOOD_Leukemia	MCM7 →	-0.454	-0.431	.001	.002	3	3
BONE	LIAS →	+0.192	+0.395	<.001	.007	3	3
PANCREAS	SIK3 →	+0.161	+1.045	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BUD23 by RNA (guanine-N7)-methylation activity — SKIN

Explore this box plot interactively →