RNA (guanine-N7)-methylation

Across TCGA cell cohorts, RNA activity of the RNA (guanine-N7)-methylation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, TMEM87B, and GOLGA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA (guanine-N7)-methylation activity versus GSR in URINARY_TRACT (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GSR →	+1.354	+1.152	.004	.003	3	4
LUNG_SCLC	TMEM87B →	-0.736	-0.125	.006	.001	3	4
KIDNEY	GOLGA2 →	-1.021	-0.818	.003	.009	3	4
LIVER	SNRPA →	+0.772	+0.895	.002	.003	3	4
SKIN	GATB →	+0.517	+0.189	<.001	.005	3	3
OESOPHAGUS	AURKC →	+0.398	+0.544	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036265 vs GSR — URINARY_TRACT

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