7-methylguanosine cap hypermethylation

Across TCGA patient cohorts, RNA activity of the 7-methylguanosine cap hypermethylation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAST3_S774, TOP2B_S1400, and FOXK1_S472, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 7-methylguanosine cap hypermethylation activity versus MAST3_S774 in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MAST3_S774 →	+0.958	+0.131	<.001	<.001	3	5
OV	TOP2B_S1400 →	+0.858	+0.145	<.001	<.001	3	4
OV	FOXK1_S472 →	+0.923	+0.146	<.001	.001	3	4
GBM	KMT2A_S142 →	-0.798	-0.094	.001	.001	3	4
HNSC	ATF7IP_S113 →	+1.010	+0.115	<.001	<.001	3	4
OV	HNRNPD →	+0.426	+0.131	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036261 vs MAST3_S774 — PDAC

Explore this scatter interactively →