Multivesicular body organization

Across TCGA patient cohorts, RNA activity of the Multivesicular body organization pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMF1, MBD5, and PARGP1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multivesicular body organization activity versus TMF1 in UVM (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	TMF1 →	+1.640	+0.058	<.001	<.001	3	33
CHOL	MBD5 →	+0.985	+0.056	<.001	<.001	3	33
THYM	PARGP1 →	+0.945	+0.050	<.001	<.001	3	33
UVM	DDX17 →	+1.287	+0.051	<.001	<.001	3	32
UVM	TBC1D12 →	+1.053	+0.058	<.001	<.001	3	32
THYM	SASH1 →	+1.534	+0.050	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036257 vs TMF1 — UVM

Explore this scatter interactively →