Multivesicular body organization

Across TCGA patient cohorts, RNA activity of the Multivesicular body organization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSA2P5, SNX9, and VEZTP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multivesicular body organization activity versus NSA2P5 in OV (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NSA2P5 →	-0.916	-0.170	.002	.006	3	5
CCRCC	SNX9 →	+0.191	+0.106	.006	.009	3	4
COAD	VEZTP1 →	-0.154	-0.165	<.001	<.001	3	4
HNSC	SNX22 →	-0.439	-0.099	.002	.003	3	4
HNSC	C15orf61 →	-0.390	-0.094	<.001	.006	3	4
GBM	HSFX4 →	-0.220	-0.138	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036257 vs NSA2P5 — OV

Explore this scatter interactively →