Multivesicular body organization

Across TCGA cell cohorts, RNA activity of the Multivesicular body organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL4R, KIAA1217, and ZNF888, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL4R grouped by Multivesicular body organization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IL4R →	+1.488	+0.298	.001	.005	3	6
URINARY_TRACT	KIAA1217 →	+2.275	+0.306	.001	.003	3	5
LUNG_NSCLC_LUAD	ZNF888 →	+0.910	+0.207	.001	.004	3	5
BREAST	ZNF468 →	+0.869	+0.236	.008	.007	3	5
PANCREAS	SPTLC3 →	+1.202	+0.230	.004	.002	3	4
URINARY_TRACT	KIAA0040 →	+3.557	+0.383	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL4R by Multivesicular body organization activity — URINARY_TRACT

Explore this box plot interactively →