Granulocyte activation

Across TCGA patient cohorts, RNA activity of the Granulocyte activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1F, FYB1, and ARHGAP9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granulocyte activation activity versus MYO1F in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1F →	+0.759	+0.354	<.001	<.001	3	9
GBM	FYB1 →	+0.811	+0.258	<.001	<.001	3	9
HNSC	ARHGAP9 →	+0.775	+0.217	.002	<.001	3	9
HNSC	CYTH4 →	+0.868	+0.199	.001	.001	3	8
COAD	LILRB1 →	+0.680	+0.197	<.001	<.001	3	8
OV	BIN2 →	+0.749	+0.144	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036230 vs MYO1F — GBM

Explore this scatter interactively →