Phosphatidylethanolamine acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Phosphatidylethanolamine acyl-chain remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH1A1, ASCC1, and ABLIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylethanolamine acyl-chain remodeling activity versus ALDH1A1 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDH1A1 →	+0.742	+0.068	<.001	<.001	3	5
LSCC	ASCC1 →	-0.199	-0.055	<.001	.003	3	5
LSCC	ABLIM1 →	+0.353	+0.078	.001	<.001	3	5
LSCC	ME1 →	+0.577	+0.049	.003	.003	3	5
LSCC	SCIN →	+0.861	+0.064	.001	<.001	3	4
GBM	SEPTIN4 →	+0.693	+0.046	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036152 vs ALDH1A1 — GBM

Explore this scatter interactively →