Phosphatidylcholine acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERP27, LPCAT1, and CST6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine acyl-chain remodeling activity versus ERP27 in LUNG_NSCLC_LUAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ERP27 →	+2.840	+0.845	<.001	.001	3	6
LUNG_NSCLC_LUAD	LPCAT1 →	+1.151	+0.618	.006	.002	3	5
LUNG_NSCLC_LUAD	CST6 →	+3.071	+0.823	.001	<.001	3	5
OVARY	ILDR1 →	+1.776	+0.711	<.001	.009	3	5
LUNG_SCLC	GALNT3 →	+2.015	+0.876	<.001	.002	3	5
PANCREAS	ADGRG1 →	+2.992	+0.318	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036151 vs ERP27 — LUNG_NSCLC_LUAD

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