Phosphatidylserine acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Phosphatidylserine acyl-chain remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, TLN1_S2040, and EFEMP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylserine acyl-chain remodeling activity versus SORBS3 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SORBS3 →	+0.435	+0.060	.001	.008	3	6
LSCC	TLN1_S2040 →	+0.575	+0.060	<.001	<.001	3	6
CCRCC	EFEMP1 →	+0.798	+0.043	<.001	<.001	3	6
BRCA	UCHL5 →	-0.213	-0.034	.007	.004	3	6
CCRCC	EFEMP2 →	+0.727	+0.038	<.001	.003	3	6
CCRCC	MFAP4 →	+1.172	+0.045	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036150 vs SORBS3 — UCEC

Explore this scatter interactively →