Phosphatidylserine acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Phosphatidylserine acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JADE3, RPL21, and COMMD6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylserine acyl-chain remodeling activity versus JADE3 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JADE3 →	-0.617	-0.538	<.001	.003	3	4
LUAD	RPL21 →	-0.343	-0.523	<.001	.009	3	4
LUAD	COMMD6 →	-0.321	-1.046	.001	<.001	3	4
BRCA	MGAT3 →	-0.862	-0.701	<.001	<.001	3	4
CCRCC	CCNB1IP1 →	-0.524	-0.354	<.001	.007	3	4
LSCC	TUBA4A →	+0.506	+0.625	.006	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036150 vs JADE3 — GBM

Explore this scatter interactively →