Phosphatidylserine acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylserine acyl-chain remodeling pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAD9, COL28A1, and ITGB6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACAD9 grouped by Phosphatidylserine acyl-chain remodeling-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACAD9 →	+0.354	+1.526	.004	.003	3	3
LUNG_NSCLC_LUAD	COL28A1 →	-0.081	-0.310	.004	.001	2	4
BLOOD_Leukemia	ITGB6 →	+0.263	+0.379	.001	<.001	3	3
CNS	PRKAR2A →	-0.499	-0.386	.003	.005	3	2
BLOOD_Leukemia	FOXL1 →	+0.132	+0.379	.003	<.001	2	3
SKIN	ZNF639 →	+0.145	+0.489	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACAD9 by Phosphatidylserine acyl-chain remodeling activity — BREAST

Explore this box plot interactively →