Phosphatidylinositol acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOSL1, PHB2, and PTMA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol acyl-chain remodeling activity versus FOSL1 in BLOOD_Leukemia (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FOSL1 →	+2.491	+1.352	.003	.001	3	6
STOMACH	PHB2 →	-1.073	-1.205	<.001	.004	3	5
BLOOD_Leukemia	PTMA →	-0.963	-0.934	<.001	.006	3	5
BLOOD_Leukemia	MBOAT7 →	+1.161	+1.399	<.001	.002	3	5
URINARY_TRACT	THBS1 →	+5.227	+1.373	<.001	.005	3	4
CNS	PCDH1 →	+2.118	+1.019	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036149 vs FOSL1 — BLOOD_Leukemia

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