Phosphatidylglycerol acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylglycerol acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPGAT1, IKBIP, and EPS8L1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol acyl-chain remodeling activity versus LPGAT1 in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LPGAT1 →	+1.159	+0.221	<.001	<.001	3	13
BONE	IKBIP →	+1.622	+0.146	<.001	<.001	3	8
PANCREAS	EPS8L1 →	-2.341	-0.144	<.001	<.001	3	8
OESOPHAGUS	CNKSR1 →	-1.994	-0.176	.003	.001	3	7
OESOPHAGUS	ST14 →	-3.318	-0.125	.001	.002	3	7
PANCREAS	MAPK13 →	-2.397	-0.189	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036148 vs LPGAT1 — STOMACH

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