Response to platelet-derived growth factor

Across TCGA patient cohorts, RNA activity of the Response to platelet-derived growth factor pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, GUCY1B1, and PALM2AKAP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to platelet-derived growth factor activity versus VCL in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VCL →	+0.451	+0.060	<.001	<.001	3	10
LSCC	GUCY1B1 →	+0.497	+0.077	<.001	<.001	3	9
BRCA	PALM2AKAP2 →	+0.370	+0.021	<.001	.008	3	9
UCEC	FILIP1L →	+0.594	+0.064	.002	.008	3	9
OV	CLEC3B →	+0.611	+0.048	.004	.002	3	9
OV	SNX9 →	+0.451	+0.065	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036119 vs VCL — GBM

Explore this scatter interactively →